Human α-Adducin Gene, Blood Pressure, and Sodium Metabolism
نویسندگان
چکیده
منابع مشابه
Human a-Adducin Gene, Blood Pressure, and Sodium Metabolism
The adducin genes contribute significantly to population variation in rat blood pressure and cell membrane sodium transport. The 460Trp mutation of the human a-adducin gene has been associated with hypertension, in particular hypertension sensitive to sodium restriction. We studied the relationship between the 460Trp mutation and population variation in blood pressure and sodium metabolism. Fro...
متن کاملPhysiological Interaction Between -Adducin and WNK1-NEDD4L Pathways on Sodium-Related Blood Pressure Regulation
The kidney plays an important role in salt and blood pressure (BP) homeostasis. In previous studies, variants in the genes for -adducin (ADD1), WNK1, and NEDD4L, which all regulate renal sodium absorption, have been associated with increased BP. However, findings have been inconsistent. We tested whether this is because of physiological interactions between the effects of variants in these gene...
متن کاملPhysiological interaction between alpha-adducin and WNK1-NEDD4L pathways on sodium-related blood pressure regulation.
The kidney plays an important role in salt and blood pressure (BP) homeostasis. In previous studies, variants in the genes for alpha-adducin (ADD1), WNK1, and NEDD4L, which all regulate renal sodium absorption, have been associated with increased BP. However, findings have been inconsistent. We tested whether this is because of physiological interactions between the effects of variants in these...
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متن کاملDietary sodium and blood pressure.
The importance of dietary sodium chloride in the regulation of blood pressure has received much attention over the past few years. This area of research and knowledge has been controversial for several reasons. The major reason for controversy is that the science of the relationship is difficult to ascertain. Population science is limited by the narrow range of dietary sodium intake by most pop...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1998
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.32.1.138